Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been
recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of …

Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …

Synthetic biologists are exploiting biofilms as an effective mechanism for producing various
outputs. Metabolic optimization has become commonplace as a method of maximizing …

Bacterial biofilms affect many areas of human activity including food processing,
transportation, public infrastructure, and most importantly healthcare. This study addresses …

Staphylococcus aureus is a major human pathogen whose characteristics support its
success in various clinical settings including Cystic Fibrosis (CF). In CF, S. aureus is indeed …

Rationale: Progress has been made in understanding how the cystic fibrosis (CF) basic
defect produces lung infection susceptibility. However, it remains unclear why CF …

Lipopolysaccharides, major molecules in the outer membrane of Gram-negative bacteria,
play important roles on membrane integrity of the cell. However, how the core …

Lipopolysaccharides (LPS) are the main components of the outer membrane of Gram-
negative bacteria. They are glycolipids containing a lipid moiety called lipid A, more often …

The intrinsic resistance of Pseudomonas aeruginosa to polymyxins in part relies on the
addition of 4-amino-4-deoxy-l-arabinose (Ara4N) molecules to the lipid A of …

Antibody-based therapeutics have become a major class of therapeutics with over 120
recombinant antibodies approved or under review in the EU or US. This therapeutic class …