Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways
is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we …

Aging is associated with changes in a variety of biological processes at the transcriptomic
level, including gene expression. Two types of aging occur during a lifetime: chronological …

Olfactory neurons allow animals to discriminate nutritious food sources from potential
pathogens. From a forward genetic screen, we uncovered a surprising requirement for the …

Aging and immunity are inextricably linked and many genes that extend life span also
enhance immunoresistance. However, it remains unclear whether longevity‐enhancing …

Host metabolism is profoundly altered during bacterial infection, both as a consequence of
immune activation and secondary to virulence strategies of invading pathogens. As a result …

Flavin containing monooxygenases (FMOs) are promiscuous enzymes known for
metabolizing a wide range of exogenous compounds. In C. elegans, fmo-2 expression …

Reproduction and immunity are energy intensive, intimately linked processes in most
organisms. In women, pregnancy is associated with widespread immunological adaptations …

As an irreplaceable dietary constituent, lipids play a vital important role in health, but their
effects on aging process and longevity are still not well known yet. In this paper, the …

Dietary lipids play an important role in human health, but their influence on aging and
longevity remains to be ascertained. This study tests the hypothesis that the consumption of …