Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …

The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

A main goal of mathematical and computational oncology is to develop quantitative tools to
determine the most effective therapies for each individual patient. This involves predicting …

Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions,
namely Crohn's disease and ulcerative colitis. Despite all advances in the management of …

Multicellular tumor spheroids are largely exploited in cancer research since they are more
predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the …

Motivation Organization of the organoid models, imaged in 3D with a confocal microscope,
is an essential morphometric index to assess responses to stress or therapeutic targets. In …

Background DNA barcoding utilises a standardised region of the cytochrome c oxidase I
(COI) gene to identify specimens to the species level. It has proven to be an effective tool for …

During space travel, astronauts will experience a unique environment that includes
continuous exposure to microgravity and stressful living conditions. Physiological adaptation …

Simple Summary Human breast cancers are not fully autonomous. They are dependent on
nutrients and growth-promoting signals provided by stromal cells. In order to instruct the …