The 5-year survival rate in esophageal cancer, although poor, has improved over the past
decade. This review discusses the epidemiologic aspects, pathogenesis, prevention, and …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

BACKGROUND AND OBJECTIVES Esophageal Cancer (EC) is a lethal malignancy with
poor prognosis and significant variations in the incidence, mortality, and histopathology …

The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …

Zinc is an essential trace element that plays important roles in the regulation of various
physiological responses in the body. Zinc deficiency is known to cause various health …

Zinc is an essential micronutrient that supports all living organisms through regulating
numerous biological processes. However, the mechanism of uptake regulation by …

The genetic mechanisms underlying the poor prognosis of esophageal squamous cell
carcinoma (ESCC) are not well understood. Here, we report somatic mutations found in …

Genome-wide association studies (GWAS) have been successful in identifying loci
associated with a wide range of complex human traits and diseases. Up to now, the majority …

The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …