The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Several non-redundant features of the tumour microenvironment facilitate
immunosuppression and limit anticancer immune responses. These include physical …

The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Inflammation is intimately related to the pathogenesis of numerous acute and chronic
diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and …

The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …

Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …

The Warburg effect is characterised by increased glucose uptake and lactate secretion in
cancer cells resulting from metabolic transformation in tumour tissue. The corresponding …

The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …