TALE (three amino acids loop extension) homeodomain transcription factors are required in
various steps of embryo development, in many adult physiological functions, and are …

We report the latest structural information on PREP1 tumor suppressor, the specific
“oncogene” and “tumor suppressive” signatures of MEIS1 and PREP1, the molecular rules …

Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the
primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and …

Many cellular processes are regulated by the coordination of several post-translational
modifications that allow a very fine modulation of substrates. Recently it has been reported …

Parkinson's disease (PD) is a progressive, primarily motor disorder that is characterized by
loss of dopaminergic (DA) neurons within the substantia nigra (SN). Cell death in PD has …

N, N-Bis-(2-chloroethyl)-phosphorodiamidic acid (phosphoramide mustard, PM) and N, N-
bis-(2-chloroethyl)-amine (nornitrogen mustard, NOR) are the two biologically active …

A number of external and internal insults disrupt nucleolar structure, and the resulting
nucleolar stress stabilizes and activates p53. We show here that nucleolar disruption …

The MYB binding protein 1A (MYBBP1A, also known as p160) acts as a co-repressor of
multiple transcription factors involved in many physiological processes. Therefore …

Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral
integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse …

MYBBP1A is a predominantly nucleolar transcriptional regulator involved in rDNA synthesis
and p53 activation via acetylation. However little further information is available as to its …