Advances and perspectives in chemical isotope labeling-based mass spectrometry methods for metabolome and exposome analysis

S Gao, X Zhou, M Yue, S Zhu, Q Liu, XE Zhao - TrAC Trends in Analytical …, 2023 - Elsevier
Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …

Recent advances in analytical approaches for glycan and glycopeptide quantitation

DG Delafield, L Li - Molecular & Cellular Proteomics, 2021 - ASBMB
Growing implications of glycosylation in physiological occurrences and human disease have
prompted intensive focus on revealing glycomic perturbations through absolute and relative …

On-tissue derivatization with Girard's reagent P enhances N-glycan signals for formalin-fixed paraffin-embedded tissue sections in MALDI mass spectrometry imaging

H Zhang, X Shi, NQ Vu, G Li, Z Li, Y Shi, M Li… - Analytical …, 2020 - ACS Publications
Glycosylation is a major protein post-translational modification whose dysregulation has
been associated with many diseases. Herein, an on-tissue chemical derivatization strategy …

Chemical tagging in mass spectrometry for systems biology

T Huang, MR Armbruster, JB Coulton… - Analytical …, 2018 - ACS Publications
Mass spectrometry (MS) offers unparalleled qualitative and quantitative chemical
information. While increasingly considered a universal detector, the limitations of MS to …

Advances in mass spectrometry‐based glycomics—An update covering the period 2017–2021

KB Donohoo, J Wang, M Goli, A Yu, W Peng… - …, 2022 - Wiley Online Library
The wide variety of chemical properties and biological functions found in proteins is attained
via post‐translational modifications like glycosylation. Covalently bonded to proteins …

21-plex DiLeu isobaric tags for high-throughput quantitative proteomics

DC Frost, Y Feng, L Li - Analytical chemistry, 2020 - ACS Publications
Isobaric tags enable multiplexed quantitative analysis of many biological samples in a single
LC-MS/MS experiment. As a cost-effective alternative to expensive commercial isobaric …

Isobaric multiplex labeling reagents for carbonyl-containing compound (SUGAR) tags: a probe for quantitative glycomic analysis

Y Feng, B Chen, Q Yu, X Zhong, DC Frost… - Analytical …, 2019 - ACS Publications
Glycans are highly complex entities with multiple building units and different degrees of
branched polymerization. Intensive research efforts have been directed to mass …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2017–2018

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …

Novel methods in glycomics: a 2019 update

WQ Cao, MQ Liu, SY Kong, MX Wu… - Expert Review of …, 2020 - Taylor & Francis
Introduction: Glycomics, which aims to define the glycome of a biological system to better
assess the biological attributes of the glycans, has attracted increasing interest. However …

Quantitative clinical glycomics strategies: a guide for selecting the best analysis approach

MW Patabandige, LD Pfeifer… - Mass spectrometry …, 2022 - Wiley Online Library
Glycans introduce complexity to the proteins to which they are attached. These modifications
vary during the progression of many diseases; thus, they serve as potential biomarkers for …