Anything but conventional chromatography approaches in bioseparation
While packed bed chromatography, known as conventional chromatography, has been
serving the biopharmaceutical industry for decades as the bioseparation method of choice …
serving the biopharmaceutical industry for decades as the bioseparation method of choice …
A workflow for the development of template-assisted membrane crystallization downstream processing for monoclonal antibody purification
N Rajoub, CJJ Gerard, E Pantuso, E Fontananova… - Nature …, 2023 - nature.com
Monoclonal antibodies (mAbs) are commonly used biologic drugs for the treatment of
diseases such as rheumatoid arthritis, multiple sclerosis, COVID-19 and various cancers …
diseases such as rheumatoid arthritis, multiple sclerosis, COVID-19 and various cancers …
Structural characterization of the full-length anti-CD20 antibody rituximab
Rituximab, a murine–human chimera, is the first monoclonal antibody (mAb) developed as a
therapeutic agent to target CD20 protein. Its Fab domain and its interaction with CD20 have …
therapeutic agent to target CD20 protein. Its Fab domain and its interaction with CD20 have …
[HTML][HTML] PEGDA hydrogel microspheres with encapsulated salt for versatile control of protein crystallization
Due to their biocompatibility and adjustable chemical structure and morphology, hydrogels
have great potential in many applications, and can be used to enhance protein crystal …
have great potential in many applications, and can be used to enhance protein crystal …
Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology
G Jacquot, P Lopez Navarro, C Grange… - Advanced …, 2024 - Wiley Online Library
In recent decades, subcutaneous (SC) administration of monoclonal antibodies (mAbs) has
emerged as a promising alternative to intravenous delivery in oncology, offering comparable …
emerged as a promising alternative to intravenous delivery in oncology, offering comparable …
Pembrolizumab microgravity crystallization experimentation
P Reichert, W Prosise, TO Fischmann, G Scapin… - npj …, 2019 - nature.com
Crystallization processes have been widely used in the pharmaceutical industry for the
manufacture, storage, and delivery of small-molecule and small protein therapeutics …
manufacture, storage, and delivery of small-molecule and small protein therapeutics …
Biopurification of monoclonal antibody (mAb) through crystallisation
Therapeutics based on monoclonal antibody (mAb) represent the most advanced
biopharmaceuticals, being able to treat a wide range of challenging diseases such as …
biopharmaceuticals, being able to treat a wide range of challenging diseases such as …
Rapid analysis for multicomponent high-throughput crystallization screening: combination of UV–vis spectroscopy and chemometrics
Selective protein crystallization is a trending alternative to preparative chromatography in
biotechnological downstream processing. To save time and resources in early-stage …
biotechnological downstream processing. To save time and resources in early-stage …
On the aggregation and nucleation mechanism of the monoclonal antibody anti-CD20 near liquid-liquid phase separation (LLPS)
E Pantuso, TF Mastropietro, ML Briuglia, CJJ Gerard… - Scientific Reports, 2020 - nature.com
The crystallization of Anti-CD20, a full-length monoclonal antibody, has been studied in the
PEG400/Na2SO4/Water system near Liquid-Liquid Phase Separation (LLPS) conditions by …
PEG400/Na2SO4/Water system near Liquid-Liquid Phase Separation (LLPS) conditions by …
Experimental Elucidation of Templated Crystallization and Secondary Processing of Peptides
The crystallization of peptides offers a sustainable and inexpensive alternative to the
purification process. In this study, diglycine was crystallised in porous silica, showing the …
purification process. In this study, diglycine was crystallised in porous silica, showing the …