Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Interferon-stimulated genes (ISGs) are a group of gene products that coordinately combat
pathogen invasions, in particular viral infections. Transcription of ISGs occurs rapidly upon …

Myxoma virus is a poxvirus naturally found in two American leporid (rabbit) species
(Sylvilagus brasiliensis and Sylvilagus bachmani) in which it causes an innocuous localised …

Oncolytic viruses are one of the most promising novel therapeutics for malignant cancers.
They selectively infect and kill cancer cells while sparing the normal counterparts, expose …

Cytokine signaling is mediated by the combinatorial usage of seven STAT proteins that form
homo-or heterodimers involved in the regulation of specific transcriptional programs. Among …

The specificity of a given virus for a cell type, tissue or species—collectively known as viral
tropism—is an important factor in determining the outcome of viral infection in any particular …

ABSTRACT STING has emerged in recent years as a key player in orchestrating innate
immune responses to cytosolic DNA and RNA derived from pathogens. However, the …

Current standard treatments of cancer can prolong survival of many cancer patients but
usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
current coronavirus disease 2019 (COVID-19) pandemic, induces an unbalanced immune …

We are being confronted with the most consequential pandemic since the Spanish flu of
1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; …