The thymus produces self-tolerant functionally competent T cells. This process involves the
import of multipotent haematopoietic progenitors that are then signalled to adopt the T cell …

GATA family transcription factors play multiple vital roles in hematopoiesis in many cell
lineages, and in particular, T cells require GATA‐3 for execution of several developmental …

Notch1 (N1) receptor signaling is essential and sufficient for T cell development, and
recently developed in vitro culture systems point to members of the Delta family as being the …

T cells developing in the adult thymus ultimately derive from haematopoietic stem cells in the
bone marrow. Here, we summarize research into the identity of the haematopoietic …

T cells originate from hematopoietic stem cells (HSCs) in the bone marrow but complete
their development in the thymus. HSCs give rise to a variety of non‐renewing hematopoietic …

In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors.
Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent …

The current dogma is that the thymus is colonized by progenitors that retain the capacity to
generate both T cells and B cells, and that intrathymic Notch signalling determines lineage …

Thymic export of cells is believed to be restricted to mature T cells. Here we show that the
thymus also exports fully committed T cell precursors that colonize primary lymphoid organs …

Intraepithelial lymphocytes (IELs) contain several subsets, but the origin of the T‐cell
receptor (TCR) αβ+ CD8αα+ IELs has been particularly controversial. Here we provide a …

Early T-lineage progenitors (ETPs) arise after colonization of the thymus by multipotent bone
marrow progenitors. ETPs likely serve as physiologic progenitors of T-cell development in …