Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

It has long been recognized that insults to the cerebral cortex, such as trauma, ischaemia or
infections, may result in the development of epilepsy, one of the most common neurological …

Perturbations in the integrity of the blood-brain barrier have been reported in both humans
and animals under numerous pathological conditions. Although the blood-brain barrier …

Early imaging studies in temporal lobe epilepsy (TLE) focused on the search for mesial
temporal sclerosis, as its surgical removal results in clinically meaningful improvement in …

Epilepsy is one of the most common neurological disorders. Although epilepsy can be
idiopathic, it is estimated that up to 50% of all epilepsy cases are initiated by neurological …

Background: Whether recurrent epileptic seizures induce brain damage is debated. Disease
progression in epilepsy has been evaluated only in a few community-based studies …

Temporal lobe epilepsy (TLE) is considered primarily a limbic disorder. Our purpose was to
map limbic network organization in TLE and to statistically relate it to neocortical atrophy. We …

Disruption of the blood–brain barrier (BBB) is a characteristic finding in common
neurological disorders. Human data suggest BBB disruption may underlie cerebral …

Drug refractory is an important clinical problem in epilepsy, affecting a substantial number of
patients globally. Mechanisms underlying drug refractory need to be understood to develop …