Precise modifications of complex genomes at the single nucleotide level have been one of
the big goals for scientists working in basic and applied genetics, including biotechnology …

F‐box and leucine‐rich repeat protein 4 (FBXL4) is a mitochondrial protein whose exact
function is not yet known. However, cellular studies have suggested that it plays significant …

Modifying the genomes of many organisms is becoming as easy as manipulating DNA in
test tubes, which is made possible by two recently developed techniques based on either …

Abstract Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by
controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central …

The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and
proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin …

Polyglutamine (polyQ) diseases describe a group of progressive neurodegenerative
disorders caused by the CAG triplet repeat expansion in the coding region of the disease …

Deregulation of the evolutionarily conserved Hippo pathway has been implicated in
abnormal development of animals and in several types of cancer. One mechanism of Hippo …

During the maternal-to-zygotic transition (MZT), which encompasses the earliest stages of
animal embryogenesis, a subset of maternally supplied gene products is cleared, thus …

The Drosophila morphogen gradient of Bicoid (Bcd) initiates anterior–posterior (AP)
patterning; however, it is poorly understood how its ability to activate a target gene may have …

Post-translational modification of histones plays essential roles in the transcriptional
regulation of genes in eukaryotes. Methylation on basic residues of histones is regulated by …