Epigenetic priming in the male germline

Y Kitamura, SH Namekawa - Current opinion in genetics & development, 2024 - Elsevier
Highlights•Epigenome regulating gene expression programs underlies male germ cell
identity and spermatogenesis.•Epigenetic priming ensure the maintenance of male germ …

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

K Cheng, Y Seita, EC Whelan, R Yokomizo, YS Hwang… - Cell Reports, 2024 - cell.com
Aberrant male germline development can lead to the formation of seminoma, a testicular
germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and …

[HTML][HTML] CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline

Y Kitamura, K Takahashi, S Maezawa, Y Munakata… - Biorxiv, 2023 - ncbi.nlm.nih.gov
Spermatogenesis is a unidirectional differentiation process that generates haploid sperm,
but how the gene expression program that directs this process is established is largely …

Impact des dommages oxydatifs de l'ADN sur la différenciation des cellules germinales

A Jampy - 2023 - theses.hal.science
Les cellules germinales (CG) sont les seules cellules capables de réaliser la méiose,
mécanisme indispensable à la formation de gamètes haploïdes nécessaires à la …