An update of Nrf2 activators and inhibitors in cancer prevention/promotion

F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

The tobacco smoke component, acrolein, as a major culprit in lung diseases and respiratory cancers: Molecular mechanisms of acrolein cytotoxic activity

P Hikisz, D Jacenik - Cells, 2023 - mdpi.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …

Curcumin—from molecule to biological function

T Esatbeyoglu, P Huebbe, IMA Ernst… - Angewandte Chemie …, 2012 - Wiley Online Library
Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in
curry and gives curry powder its characteristic yellow color. As a consequence of its intense …

Are reactive oxygen species always detrimental to pathogens?

CN Paiva, MT Bozza - Antioxidants & redox signaling, 2014 - liebertpub.com
Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Modulation of metabolic detoxification pathways using foods and food‐derived components: a scientific review with clinical application

RE Hodges, DM Minich - Journal of nutrition and metabolism, 2015 - Wiley Online Library
Research into human biotransformation and elimination systems continues to evolve.
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …

Chemical composition and health properties of coffee and coffee by-products

GV de Melo Pereira, DP de Carvalho Neto… - Advances in food and …, 2020 - Elsevier
Coffee can be an ally in the fight against diseases such as type 2 diabetes, cancer, hepatic
injury, cirrhosis, depression, suicidal behavior, and neurological and cardiovascular …

The complexity of the Nrf2 pathway: beyond the antioxidant response

Y Huang, W Li, Z Su, ANT Kong - The Journal of nutritional biochemistry, 2015 - Elsevier
The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …

Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical …

M Teymouri, M Pirro, TP Johnston, A Sahebkar - BioFactors, 2017 - Wiley Online Library
Curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for
its effects on human papilloma virus (HPV) infection as well as primary and malignant …

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

JH Lee, TO Khor, L Shu, ZY Su, F Fuentes… - Pharmacology & …, 2013 - Elsevier
Reactive metabolites from carcinogens and oxidative stress can drive genetic mutations,
genomic instability, neoplastic transformation, and ultimately carcinogenesis. Numerous …

Molecular mechanisms of curcumin action: gene expression

S Shishodia - Biofactors, 2013 - Wiley Online Library
Curcumin derived from the tropical plant Curcuma longa has a long history of use as a
dietary agent, food preservative, and in traditional Asian medicine. It has been used for …