Principles in the design of ligand-targeted cancer therapeutics and imaging agents

M Srinivasarao, CV Galliford, PS Low - Nature reviews Drug discovery, 2015 - nature.com
Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

Stepping forward in antibody-drug conjugate development

Y Jin, MA Schladetsch, X Huang, MJ Balunas… - Pharmacology & …, 2022 - Elsevier
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …

Antibody–drug conjugates: current status and future directions

HL Perez, PM Cardarelli, S Deshpande, S Gangwar… - Drug discovery today, 2014 - Elsevier
Highlights•Antibody–drug conjugates represent an exciting new class of cancer
therapeutics.•ADCs comprise monoclonal antibodies that selectively deliver potent cytotoxic …

[HTML][HTML] Antibody-drug conjugates: possibilities and challenges

MR Nejadmoghaddam, A Minai-Tehrani… - Avicenna journal of …, 2019 - ncbi.nlm.nih.gov
Abstract The design of Antibody Drug Conjugates (ADCs) as efficient targeting agents for
tumor cell is still in its infancy for clinical applications. This approach incorporates the …

PSMA-targeting imaging and theranostic agents—Current status and future perspective

S Debnath, N Zhou, M McLaughlin, S Rice… - International journal of …, 2022 - mdpi.com
In the past two decades, extensive efforts have been made to develop agents targeting
prostate-specific membrane antigen (PSMA) for prostate cancer imaging and therapy. To …

Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development

DJ Newman, GM Cragg - Marine drugs, 2014 - mdpi.com
The marine habitat has produced a significant number of very potent marine-derived agents
that have the potential to inhibit the growth of human tumor cells in vitro and, in a number of …

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

RM Hoffmann, BGT Coumbe, DH Josephs… - …, 2018 - Taylor & Francis
Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy,
combining the antibody's exquisite specificity for the target antigen-expressing cancer cell …

Preclinical and clinical status of PSMA-targeted alpha therapy for metastatic castration-resistant prostate cancer

A Juzeniene, VY Stenberg, ØS Bruland, RH Larsen - Cancers, 2021 - mdpi.com
Simple Summary Currently, there is no treatment that can cure patients with late stage
metastatic prostate cancer. Prostate-specific membrane antigen is a type of protein …

Targeted radionuclide therapy of prostate cancer—from basic research to clinical perspectives

M Czerwińska, A Bilewicz, M Kruszewski… - Molecules, 2020 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men and the second
leading cause of cancer-related deaths in Western civilization. Although localized prostate …

[HTML][HTML] Prostate-specific membrane antigen as a target for cancer imaging and therapy

AP Kiess, SR Banerjee, RC Mease… - The quarterly journal …, 2015 - ncbi.nlm.nih.gov
The prostate-specific membrane antigen (PSMA) is a molecular target whose use has
resulted in some of the most productive work toward imaging and treating prostate cancer …