MATERIALS AND METHODS Preparation of Hepatocyte Suspension-Studies were
performed utilizing rat hepatocytes in suspension isolated from male Sprague-Dawley rats …

This non‐randomized study reports pharmaco‐clinical data on 5‐FU administered by the
widely used 5‐day continuous infusion schedule to 42 patients with metastatic colorectal …

The nonlinear disposition kinetics of 5-fluorouracil (5-FU) were investigated in 6 patients
with colorectal carcinoma. Each patient randomly received two single, intravenous doses of …

Dihydrofluorouracil (FUH2) is the product of the first rate-limiting step in catabolism of 5-
fluorouracil (5-FU), catalyzed by the enzyme dihydropyrimidine dehydrogenase. In humans …

Abstract Dihydrofluorouracil (FUH2), the initial catabolite of 5-fluorouracil (FUra), was
examined to determine whether this derivative had antitumor activity or host cell (bone …

Deoxy-5-fluorouridine (5′-dFUrd) is a new antineoplastic agent which possesses a higher
therapeutic index in several experimental tumors compared to other fluoropyrimidines …

A relatively simple and sensitive high-performance liquid chromatographic (HPLC) method
is described for measuring the two anticancer drugs 5′-deoxy-5-fluorouridine (5′ dFUR) …

A mathematical model for the kinetics of 5-fluorouracil (FUra) catabolism in liver cells is
proposed. It is based on published data for the metabolism of FUra by isolated rat …

Thirty consecutive patients with metastatic breast cancer previously untreated by
chemotherapy were given high‐dose cyclophosphamide (Cytoxan) and high‐dose 5 …

Chronic weekly administration of FUra to CD8F 1 female mice bearing spontaneous
mammary tumors produced body weight loss during the first 2 weeks of treatment, which …