1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Signalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids
control important cellular processes, including cell proliferation, apoptosis, metabolism and …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases,
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …

Abstract The phospholipase A 2 (PLA 2) superfamily consists of many different groups of
enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different …

Inflammation is a network of complex processes involving a variety of metabolic and
signaling pathways aiming at healing and repairing damage tissue, or fighting infection …

The phosphorylated sphingolipid metabolites sphingosine 1-phosphate (S1P) and ceramide
1-phosphate (C1P) have emerged as potent bioactive agents. Recent studies have begun to …

Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA …

The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly
called cytosolic phospholipase A2 (cPLA2) α, cPLA2β, cPLA2γ, cPLA2δ, cPLA2ε and …

Uncontrolled inflammation is linked to poor outcomes in sepsis and wound healing, both of
which proceed through distinct inflammatory and resolution phases. Eicosanoids are a class …