Virus-like particles (VLPs) have natural structural antigens similar to those found in viruses,
making them valuable in vaccine immunization. Furthermore, VLPs have demonstrated …

Organoid technology holds great promise for regenerative medicine. Recent studies show
feasibility for bile duct tissue repair in humans by successfully transplanting cholangiocyte …

Human cholangiocyte organoids are promising for regenerative medicine applications, such
as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor …

Scientific barriers that have prevented successful xenotransplantation are being breached,
yet many ethical issues remain. Some are broad issues that accompany the adoption of …

Genetically modified animals, especially rodents, are widely used in biomedical research.
However, non-rodent models are required for efficient translational medicine and preclinical …

Background The COVID-19 pandemic showcased the power of genomic sequencing to
tackle the emergence and spread of infectious diseases. However, metagenomic …

Porcine notochordal cell-derived matrix (NCM) has anti-inflammatory and regenerative
effects on degenerated intervertebral discs. For its clinical use, safety must be assured. The …

Background Retrotransposons are the major determinants of genome sizes and they have
shaped both genes and genomes in mammalian organisms, but their overall activity …

Heterotopic cardiac transplantation in the intra-abdominal position in a large animal model
has been essential in the progression of the field of cardiac transplantation. Our group has …

Xenotransplantation with porcine organs has been recognized as a promising solution to
alleviate the shortage of organs for human transplantation. Porcine endogenous retrovirus …