Protein oligomerization: how and why

MH Ali, B Imperiali - Bioorganic & medicinal chemistry, 2005 - Elsevier
A large fraction of cellular proteins are oligomeric. Protein oligomerization may often be an
advantageous feature from the perspective of protein evolution and has probably evolved by …

Tailoring lumazine synthase assemblies for bionanotechnology

Y Azuma, TGW Edwardson, D Hilvert - Chemical Society Reviews, 2018 - pubs.rsc.org
Nanoscale compartments formed by hierarchical protein self-assembly are valuable
platforms for nanotechnology development. The well-defined structure and broad chemical …

Biosynthesis of flavocoenzymes

M Fischer, A Bacher - Natural product reports, 2005 - pubs.rsc.org
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two
molecules of ribulose 5-phosphate. The imidazole ring of GTP is hydrolytically opened …

Control of Taenia solium taeniasis/cysticercosis: The best way forward for sub-Saharan Africa?

S Gabriël, P Dorny, KE Mwape, C Trevisan, UC Braae… - Acta tropica, 2017 - Elsevier
Taenia solium taeniasis/cysticercosis is a neglected parasitic zoonosis with significant
economic and public health impacts. Control measures can be broadly grouped into …

The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system

R Ladenstein, M Fischer, A Bacher - The FEBS Journal, 2013 - Wiley Online Library
The xylene ring of riboflavin (vitamin B2) is assembled from two molecules of 3, 4‐dihydroxy‐
2‐butanone 4‐phosphate by a mechanistically complex process that is jointly catalyzed by …

Covalent coupling of Spike's receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2

Scientific reports, 2022 - nature.com
The receptor binding domain (RBD) of the Spike protein from SARS-CoV-2 is a promising
candidate to develop effective COVID-19 vaccines since it can induce potent neutralizing …

Biosynthesis of vitamin B2: structure and mechanism of riboflavin synthase

M Fischer, A Bacher - Archives of biochemistry and biophysics, 2008 - Elsevier
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two
molecules of ribulose 5-phosphate as substrates. GTP is hydrolytically opened, converted …

[HTML][HTML] Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development

R Ladenstein, E Morgunova - Biotechnology Reports, 2020 - Elsevier
Naturally occurring and computationally ab initio designed protein cages can now be
considered as extremely suitable materials for new developments in nanotechnology. Via …

A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis …

J Cassataro, KA Pasquevich, SM Estein, DA Laplagne… - Vaccine, 2007 - Elsevier
The development of an effective subunit vaccine against brucellosis is a research area of
intense interest. The enzyme lumazine synthase from Brucella spp.(BLS) is highly …

Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice

MP Mejias, G Ghersi, PO Craig, CA Panek… - The Journal of …, 2013 - journals.aai.org
The striking feature of enterohemorrhagic Escherichia coli (EHEC) infections is the
production of Shiga toxins (Stx) implicated in the development of the life-threatening …