Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Pericytes are known as the mural cells in small-caliber vessels that interact closely with the
endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when …

Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

Subcortical small-vessel disease (SSVD) is a disorder well characterized from the clinical,
imaging, and neuropathological viewpoints. SSVD is considered the most prevalent …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common monogenic disorder of the cerebral …

Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular
domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a …

Arteriovenous malformations (AVMs) are high-flow lesions directly connecting arteries and
veins. In the brain, AVM rupture can cause seizures, stroke, and death. Patients with AVMs …

Diabetic macular edema is a major complication of diabetes resulting in loss of central
vision. Although heightened vessel leakiness has been linked to glial and neuronal-derived …

The incidence and severity of cerebrovascular disease (CVD) increase with advancing age,
as does the risk of developing Alzheimer's disease (AD). Not surprisingly, heterogeneous …

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control
cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …