Mitochondrial metabolism in hibernation: regulation and implications

JF Staples, KE Mathers, BM Duffy - Physiology, 2022 - journals.physiology.org
Hibernators rapidly and reversibly suppress mitochondrial respiration and whole animal
metabolism. Posttranslational modifications likely regulate these mitochondrial changes …

Understanding the scientific validity of synthetic torpor for radiation research and extended space missions

AP Kokko, R Chowdhury, K Sherman… - Frontiers in Space …, 2024 - frontiersin.org
The idea of synthetic torpor, an artificial state resembling the hypo-metabolic state of
torpor/hibernation, has recently gained significant scientific attention. Building on pioneering …

Synthetic torpor protects rats from exposure to accelerated heavy ions

A Puspitasari, F Squarcio, M Quartieri, C Totis… - Scientific reports, 2022 - nature.com
Hibernation or torpor is considered a possible tool to protect astronauts from the deleterious
effects of space radiation that contains high-energy heavy ions. We induced synthetic torpor …

[HTML][HTML] Multiorgan ultrastructural changes in rats induced in synthetic torpor

S Salucci, T Hitrec, E Piscitiello… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Torpor is a state used by several mammals to survive harsh winters and avoid predation,
characterized by a drastic reduction in metabolic rate followed by a decrease in body …

Mitochondrial Metabolism in Hibernation: Regulation and Implications

BM Duffy - journals.physiology.org
Small animals have a high body surface area relative to volume, so they lose heat rapidly at
cold ambient temperature (Ta). To compensate for this high rate of heat loss, most small …