Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

C Sun, CO Swoboda, FM Morales, C Calvo… - Nature …, 2024 - nature.com
Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …

Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation

P Garcia, W Jarassier, C Brun, L Giordani, F Agostini… - Developmental Cell, 2024 - cell.com
The histone H3 lysine 9 methyltransferase SETDB1 controls transcriptional repression to
direct stem cell fate. Here, we show that Setdb1 expression by adult muscle stem cells …

Asynchronous Pattern of MAPKs' Activity during Aging of Different Tissues and of Distinct Types of Skeletal Muscle

N Gilad, MP Mohanam, I Darlyuk-Saadon… - International Journal of …, 2024 - mdpi.com
The MAPK p38α was proposed to be a prominent promoter of skeletal muscle aging. The
skeletal muscle tissue is composed of various muscle types, and it is not known if p38α is …

[HTML][HTML] Lineage tracing of newly accrued nuclei in skeletal myofibers uncovers distinct transcripts and interplay between nuclear populations

C Sun, CO Swoboda, MJ Petrany, S Parameswaran… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Multinucleated skeletal muscle cells have an obligatory need to acquire additional nuclei
through fusion with activated skeletal muscle stem cells when responding to both …

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

P Garcia, W Jarassier, C Brun, L Giordani, F Agostini… - bioRxiv, 2023 - biorxiv.org
Modulations in chromatin structure orchestrate gene expression and direct stem cell fate.
More specifically, the Histone 3 Lysine 9 Methyltransferase SETDB1 controls transcriptional …

Identification and Analysis of Myogenic Progenitors In Vivo During Acute Skeletal Muscle Injury by High-Dimensional Single-Cell Mass Cytometry

SH Andersen, TR Kjær, K Ghimire… - JoVE (Journal of Visualized …, 2023 - jove.com
Skeletal muscle regeneration is a dynamic process driven by adult muscle stem cells and
their progeny. Mostly quiescent at a steady state, adult muscle stem cells become activated …

Novel single-cell technologies advance our mechanistic understanding of muscle stem cell function in skeletal muscle regeneration

E Porpiglia, HM Blau - Revealing Unchartered Biology with Single Intact …, 2024 - Elsevier
Regenerative medicine aims to understand the cellular and molecular processes underlying
effective tissue repair with the long-term goal of restoring structure and function to damaged …