Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …

Imidazole remains a privileged heterocycle in drug discovery. Imidazole scaffold is a
ubiquitous motif that is present in several pharmacologically important drug molecules such …

Azole antifungal drugs are used worldwide to treat a variety of fungal infections such as
vulvovaginal candidiasis, particularly in pregnant women who are at increased risk. The aim …

Abstract Development of Multitarget-Directed Ligands (MTDLs) is a promising approach to
combat the complex etiologies of Alzheimer's disease (AD). Herein we report the design …

The emergence of untreatable drug‐resistant strains of Mycobacterium tuberculosis is a
major public health problem worldwide, and the identification of new efficient treatments is …

A series of imidazole and triazole diarylpyrazole derivatives were prepared using an efficient
5-step synthetic scheme and evaluated for binding affinity with Mycobacterium tuberculosis …

Mycobacterium tuberculosis (Mtb) has numerous cell wall and non‐cell wall mediated
receptors for drug action, of which cell wall mediated targets were found to be more …

The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the
development of TB drugs with different mechanisms of action. The genome sequence of …

This paper reports on the design of a series of 10 novel lipophilic piperazinyl derivatives of
the 1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid, their …