Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
This disease impairs patients' quality of life enormously. Pathological findings demonstrate …

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …

Psoriasis vulgaris and other chronic inflammatory diseases improve markedly with
therapeutic blockade of interleukin-23 (IL-23) signaling, but the genetic mechanisms …

Sarcoidosis is a disease of unknown etiology in which granulomas form throughout the body
and is typically treated with glucocorticoids, but there are no approved steroid-sparing …

A key challenge in psoriasis therapy is the tendency for lesions to recur in previously
affected anatomical locations after treatment discontinuation following lesion resolution …

Atopic dermatitis (AD) is a skin disease that is heterogeneous both in terms of clinical
manifestations and molecular profiles. It is increasingly recognized that AD is a systemic …

In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …

Dendritic cells (DCs) are currently considered to be of utmost importance for orchestrating
appropriate immune responses in vivo, and play critical roles in maintaining the distinction …

Abstract Background Dendritic cells (DCs) mediate divergent immune effects by activating T
cells or negatively regulating the immune response to promote immune tolerance. They …