Podocytopathies

JB Kopp, HJ Anders, K Susztak, MA Podestà… - Nature Reviews …, 2020 - nature.com
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Idiopathic nephrotic syndrome in children

DG Noone, K Iijima, R Parekh - The Lancet, 2018 - thelancet.com
The incidence of idiopathic nephrotic syndrome (NS) is 1· 15–16· 9 per 100 000 children,
varying by ethnicity and region. The cause remains unknown but the pathogenesis of …

IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome

A Trautmann, O Boyer, E Hodson, A Bagga… - Pediatric …, 2023 - Springer
Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting
from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive …

Epidemiology and pathophysiology of nephrotic syndrome–associated thromboembolic disease

BA Kerlin, R Ayoob, WE Smoyer - Clinical Journal of the American …, 2012 - journals.lww.com
After infections, thromboembolism is considered by many experts to be the most significant
life-threatening complication of nephrotic syndrome. The purpose of this review is to …

An eQTL landscape of kidney tissue in human nephrotic syndrome

CE Gillies, R Putler, R Menon, E Otto… - The American Journal of …, 2018 - cell.com
Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression
and, in disease research, can be particularly illuminating when using the tissues directly …

Evidence-based clinical practice guidelines for nephrotic syndrome 2014

S Nishi, Y Ubara, Y Utsunomiya, K Okada… - Clinical and …, 2016 - Springer
In Japan, original researches on nephrotic syndrome (NS) were initially performed by the
Ministry of Health, Labour and Welfare (MHLW) NS research group. The first definition of NS …

Childhood nephrotic syndrome

M Vivarelli, K Gibson, A Sinha, O Boyer - The Lancet, 2023 - thelancet.com
Idiopathic nephrotic syndrome is the most common glomerular disease in children.
Corticosteroids are the cornerstone of its treatment, and steroid response is the main …

[HTML][HTML] Risk factors for in-hospital venous thromboembolism in children: a case-control study employing diagnostic validation

BR Branchford, P Mourani, L Bajaj… - …, 2012 - ncbi.nlm.nih.gov
Background Studies evaluating risk factors for in-hospital venous thromboembolism in
children are limited by quality assurance of case definition and/or lack of controlled …

The Italian Society for Pediatric Nephrology (SINePe) consensus document on the management of nephrotic syndrome in children: Part I-Diagnosis and treatment of …

A Pasini, E Benetti, G Conti, L Ghio, M Lepore… - Italian journal of …, 2017 - Springer
This consensus document is aimed at providing an updated, multidisciplinary overview on
the diagnosis and treatment of pediatric nephrotic syndrome (NS) at first presentation. It is …

Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

A Barry, MT McNulty, X Jia, Y Gupta, H Debiec… - Nature …, 2023 - nature.com
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood
glomerular disease. Previous genome-wide association studies (GWAS) identified a risk …