[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Endocannabinoid signaling in the central nervous system

CE Martinez Ramirez, G Ruiz‐Pérez, TM Stollenwerk… - Glia, 2023 - Wiley Online Library
It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

Photoredox-Catalyzed C–H Trideuteromethylation of Quinoxalin-2(1H)-ones with CDCl3 as the “CD3” source

MC Wu, MZ Li, YX Chen, F Liu, JA Xiao, K Chen… - Organic …, 2022 - ACS Publications
Herein, readily available and inexpensive CDCl3 was first identified as a new
trideuteromethylation reagent under photoredox-catalyzed conditions. Thus, a facile …

Catalytic Contra-Thermodynamic Isomerization–Asymmetric Hydroboration of Alkenyl Alcohols and Amines

C Li, K Zhang, W Zhao - ACS Catalysis, 2024 - ACS Publications
Catalytic isomerization of alkenes is a powerful tool for the construction of complex
synthetically valuable molecules due to their redox-neutral, atom-and step-economical …

Understanding and Targeting the Endocannabinoid System with Activity‐Based Protein Profiling

N Zhu, APA Janssen… - Israel Journal of …, 2023 - Wiley Online Library
The endocannabinoid system (ECS) is a widespread modulatory system composed of
cannabinoid receptors, endogenous signaling lipids termed endocannabinoids and the …

Small molecule activation of NAPE-PLD enhances efferocytosis by macrophages

JE Zarrow, AM Alli-Oluwafuyi, CM Youwakim… - ACS chemical …, 2023 - ACS Publications
N-Acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) is a zinc
metallohydrolase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to form N-acyl …

HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme

T Lange, T Depmeier, T Strünker, M Lehr - Journal of Pharmaceutical and …, 2023 - Elsevier
N-Acyl phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) is the major
enzyme for the biosynthesis of the endocannabinoid anandamide. The role of NAPE-PLD in …

Selective measurement of NAPE-PLD activity via a PLA1/2-resistant fluorogenic N-acyl-phosphatidylethanolamine analog

JE Zarrow, J Tian, B Dutter, K Kim, AC Doran… - Journal of lipid …, 2022 - ASBMB
Abstract N-acyl-phosphatidylethanolamine (NAPE)-hydrolyzing phospholipase D (NAPE-
PLD) is a zinc metallohydrolase enzyme that converts NAPEs to bioactive N-acyl …

The Development of Chemical Probes for Detecting and Modulating NAPE-PLD Activity

JE Zarrow - 2023 - search.proquest.com
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) is a zinc
metallohydrolase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to form N-acyl …

[PDF][PDF] Silyl Borane-mediated or Mechanochemical Promoted C–F Bond Activation of Fluorinated Compounds

Z ZHAO - nitech.repo.nii.ac.jp
Through the centuries, fluorinated compounds have become indispensable yet controversial
chemicals in both industrial and our daily life. Ever Since Polytetrafluoroethylene (PTFE) …