Metabolons, enzyme–enzyme assemblies that mediate substrate channeling, and their roles in plant metabolism

Y Zhang, AR Fernie - Plant Communications, 2021 - cell.com
Metabolons are transient multi-protein complexes of sequential enzymes that mediate
substrate channeling. They differ from multi-enzyme complexes in that they are dynamic …

Recent advances in proteomics and metabolomics in plants

S Yan, R Bhawal, Z Yin, TW Thannhauser… - Molecular Horticulture, 2022 - Springer
Over the past decade, systems biology and plant-omics have increasingly become the main
stream in plant biology research. New developments in mass spectrometry and …

Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

Y Zhang, L Wiese, H Fang, S Alseekh, LP de Souza… - Molecular Plant, 2023 - cell.com
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …

A highly efficient agrobacterium-mediated method for transient gene expression and functional studies in multiple plant species

Y Zhang, M Chen, B Siemiatkowska, MR Toleco… - Plant …, 2020 - cell.com
Although the use of stable transformation technology has led to great insight into gene
function, its application in high-throughput studies remains arduous. Agro-infiltration have …

A moonlighting role for enzymes of glycolysis in the co-localization of mitochondria and chloroplasts

Y Zhang, A Sampathkumar, SML Kerber… - Nature …, 2020 - nature.com
Glycolysis is one of the primordial pathways of metabolism, playing a pivotal role in energy
metabolism and biosynthesis. Glycolytic enzymes are known to form transient multi-enzyme …

The formation and function of plant metabolons

I Dahmani, K Qin, Y Zhang, AR Fernie - The Plant Journal, 2023 - Wiley Online Library
Metabolons are temporary structural‐functional complexes of sequential enzymes of a
metabolic pathway that are distinct from stable multi‐enzyme complexes. Here we provide a …

Depicting the genetic and metabolic panorama of chemical diversity in the tea plant

H Qiu, X Zhang, Y Zhang, X Jiang… - Plant Biotechnology …, 2024 - Wiley Online Library
As a frequently consumed beverage worldwide, tea is rich in naturally important bioactive
metabolites. Combining genetic, metabolomic and biochemical methodologies, here, we …

Two mitochondrial phosphatases, PP2c63 and Sal2, are required for posttranslational regulation of the TCA cycle in Arabidopsis

Y Zhang, J Giese, SM Kerbler, B Siemiatkowska… - Molecular Plant, 2021 - cell.com
Protein phosphorylation is a well-established post-translational mechanism that regulates
protein functions and metabolic pathways. It is known that several plant mitochondrial …

Evolution of cytosolic and organellar invertases empowered the colonization and thriving of land plants

H Wan, Y Zhang, L Wu, G Zhou, L Pan… - Plant …, 2023 - academic.oup.com
The molecular innovation underpinning efficient carbon and energy metabolism during
evolution of land plants remains largely unknown. Invertase-mediated sucrose cleavage into …

Overview of methods for characterization and visualization of a protein–protein interaction network in a multi-omics integration context

V Robin, A Bodein, MP Scott-Boyer… - Frontiers in Molecular …, 2022 - frontiersin.org
At the heart of the cellular machinery through the regulation of cellular functions, protein–
protein interactions (PPIs) have a significant role. PPIs can be analyzed with network …