Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Folliculin (FLCN) is a tumor suppressor gene responsible for the inherited Birt-Hogg-Dubé
(BHD) syndrome, which affects kidneys, skin and lungs. FLCN is a highly conserved protein …

Summary mTORC1 controls anabolic and catabolic processes in response to nutrients
through the Rag GTPase heterodimer, which is regulated by multiple upstream protein …

A simplified and cost-effective culture system for maintaining the pluripotency of human
induced pluripotent stem cells (hiPSCs) is crucial for stem cell applications. Although …

The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3,
MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject …

Embryonic diapause is an enigmatic state of dormancy that interrupts the normally tight
connection between developmental stages and time. This reproductive strategy and state of …

Forward genetic screens are a powerful and unbiased approach for uncovering the genetic
basis behind a specific phenotype. Genome-wide mutagenesis followed by phenotypic …

Initially described as lytic bodies due to their degradative and recycling functions, lysosomes
play a critical role in metabolic adaptation to nutrient availability. More recently, the …

The Golgi apparatus modifies and transports secretory and membrane proteins. In some
instances, the production of secretory and membrane proteins exceeds the capacity of the …

Purpose: Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal soft tissue
neoplasm often linked to mTOR pathway activation via TSC2 mutation. We analyzed a …