Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Meninges that surround the CNS consist of an outer fibrous sheet of dura mater
(pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the …

Autotransporters are the core component of a molecular nano-machine that delivers cargo
proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion …

The field of genetics has expanded a lot in the past few decades due to the accessibility of
human genome sequences, but still, the regulation of transcription cannot be explicated …

Pathogenic bacteria secrete a variety of proteins that manipulate host cell function by
targeting components of the plasma membrane, cytosol, or organelles. In the last decade …

Through long-term interactions with their hosts, bacterial pathogens have evolved unique
arsenals of effector proteins that interact with specific host targets and reprogram the host …

Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the
human nasopharynx. It shares and competes for this niche with a number of other Neisseria …

Post-translational modifications (PTMs) of histone proteins play a crucial role in the
regulation of chromatin structure and functions. Studies in the last few decades have …

Neisseria meningitidis (the meningococcus) is a member of the normal nasopharyngeal
microbiome in healthy individuals, but can cause septicemia and meningitis in susceptible …

Neisseria meningitidis is a Gram-negative bacterial pathogen that normally resides as a
commensal in the human nasopharynx but occasionally causes disease with high mortality …