Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …

Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Background Glioblastoma multiforme (GBM) is the most common cancer of the central
nervous system, while Parkinson's disease (PD) is a degenerative neurological condition …

Microglia play critical roles in brain development, homeostasis, and neurological disorders.
Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to …

The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …