Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Circular dichroism (CD) spectroscopy is a well-established technique for studying the
secondary structures, dynamics, folding pathways, and interactions of soluble proteins, and …

INTRODUCTION Almost all venoms contain toxins that modulate the activity of voltage-gated
sodium (Nav) channels in order to incapacitate prey or predators. The single-chain …

Nuclear factor kappa B (NFkB) transcription factors are responsible for the regulation of
more than 150 target genes, their expression is induced by many classes of stimuli, and …

Voltage-gated sodium (Na V) channels initiate action potentials in nerve, muscle, and other
electrically excitable cells. The structural basis of voltage gating is uncertain because the …

Abstract The field of Membrane Protein Structural Biology has grown significantly since its
first landmark in 1985 with the first three-dimensional atomic resolution structure of a …

Electrical signals generated by minute currents of ions moving across cell membranes are
central to all rapid processes in biology. Initiation and propagation of electrical signals …

Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …