The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …

Solid tumours comprise many different cell types organized in spatially structured
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which
can enhance tumor progression and spread. Here, we undertook an unbiased temporal …

Biomechanical contributions of the extracellular matrix underpin cell growth and
proliferation, differentiation, signal transduction, and other fate decisions. As such …

Mammalian members of the lysyl oxidase (LOX) family of proteins carry a copper-dependent
monoamine oxidase domain exclusively within the C-terminal region, which catalyzes ε …

Background: Cholangiocarcinoma (CCA) features highly desmoplastic stroma that promotes
structural and functional resistance to therapy. Lysyl oxidases (LOX, LOXL1–4) catalyze …

Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …

The extracellular matrix (ECM) provides structural support for tissues and regulatory signals
for resident cells. ECM requires a careful balance between protein accumulation and …

Purpose: To explore the cellular cross-talk of tumor-resident mast cells (MC) in controlling
the activity of cancer-associated fibroblasts (CAF) to overcome tumor microenvironment …