Endoplasmic reticulum (ER) luminal Ca2+ is vital for the function of the ER and regulates
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …

Significance: The primary role of platelets is to generate a thrombus by platelet activation.
Platelet activation relies on calcium mobilization from the endoplasmic reticulum (ER). ER …

TWAS have shown great promise in extending GWAS loci to a functional understanding of
disease mechanisms. In an effort to fully unleash the TWAS and GWAS information, we …

Background Impairment of regulatory T (Treg) cells function is implicated in the
pathogenesis of immune imbalance-mediated cognitive impairment. A complete …

Cancer metastases into the brain constitute one of the most severe, but not uncommon,
manifestations of cancer progression. Several factors control how cancer cells interact with …

The circadian system regulates 24‐h time‐of‐day patterns of cardiovascular physiology, with
circadian misalignment resulting in adverse cardiovascular risk. Although many proteins in …

One of the key events in viral encephalitis is the ability of virus to enter the central nervous
system (CNS). Several encephalitic viruses, including La Crosse Virus (LACV), primarily …

The NleGs are the largest family of type 3 secreted effectors in attaching and effacing (A/E)
pathogens, such as enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli …

Programmed cell death is intricately linked to various physiological phenomena such as
growth, development, and metabolism, as well as the proper function of the pancreatic β cell …

Platelets have recently surfaced as critical players in cancer metastasis and the local and
systemic responses to tumor growth. The emerging concept of" Tumor-educated platelets …