Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …

The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-
dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of …

Beyond their established role as oxygen carriers, red blood cells have recently been found
to contribute to systemic NO and sulfide metabolism and act as potent circulating antioxidant …

Co-fractionation mass spectrometry (CF-MS) uses biochemical fractionation to isolate and
characterize macromolecular complexes from cellular lysates without the need for affinity …

Protein disulfide isomerases (PDIs) are involved in many intracellular and extracellular
processes, including cell adhesion and cytoskeletal reorganisation, but their contribution to …

The high-efficiency energy conversion process in organisms is usually carried out by
organelles, proteins and membrane systems. Inspired by the cellular aerobic respiration …

In the cellular context, proteins participate in communities to perform their function. The
detection and identification of these communities as well as in‐community interactions has …

There is a growing interest in characterizing the structure and dynamics of large
biomolecular assemblies and their interactions within the cellular environment. A diverse …

The Fourier shell correlation (FSC) is a measure of the similarity between two signals
computed over corresponding shells in the frequency domain and has broad applications in …