The recent development of whole genome association studies has lead to the robust
identification of several loci involved in different common human diseases. Interestingly …

IRF8 (Interferon Regulatory Factor 8) plays an important role in defenses against
intracellular pathogens, including several aspects of myeloid cells function. It is required for …

Positional cloning of the quantitative trait locus (QTL) still encounters numerous difficulties,
which explains why thousands of QTL have been mapped, while only a few have been …

Seasonal influenza outbreaks and recurrent influenza pandemics present major challenges
to public health. By studying immunological responses to influenza in different host species …

In gene targeting experiments, the importance of genetic background is now widely
appreciated, and knockout alleles are routinely backcrossed onto a standard inbred …

Allelic variations in gene expression influence many biological responses and cause
phenotypic variations in humans. In this study, Illumina Human Exome BeadChips …

Introduction Normal gene expression variation is thought to play a central role in inter-
individual variation and susceptibility to disease. Regulatory polymorphisms in cis-acting …

Complex traits are under the genetic control of multiple genes, often with weak effects and
strong epistatic interactions. We developed two new collections of mouse strains to improve …

Background Changes in gene expression are known to be responsible for phenotypic
variation and susceptibility to diseases. Identification and annotation of the genomic …

Thoracic cavity radiotherapy is limited by the development of alveolitis and fibrosis in
susceptible patients. To define the response to 18 Gy pulmonary irradiation in mice at the …