Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis

C Zhang, Y Liu, X Liu, X Chen, R Chen - Molecules, 2023 - mdpi.com
Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables,
fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural …

A Synthetic Approach to Several C7-Carbasugars via a Key Intramolecular Morita–Baylis–Hillman Reaction

Y Jia, M Wang, F Wu, Y Wang… - The Journal of Organic …, 2022 - ACS Publications
A new synthetic strategy for C7-carbasugars is developed via an intramolecular Morita–
Baylis–Hillman reaction, in which a substituted dial precursor prepared from d-mannose …

Convergent formal synthesis of ecteinascidin 743

J Jia, R Chen, Y Jia, H Gu, Q Zhou… - The Journal of Organic …, 2019 - ACS Publications
A concise formal synthesis of ecteinascidin 743 is described. Key features involve the
coupling of the multisubstituted tetrahydroisoquinoline and phenylalaninol moieties via a …

Application of a tandem seleno-michael/aldol reaction in the total syntheses of (+)-Pericosine B,(+)-Pericosine C,(+)-COTC and 7-chloro-analogue of (+)-Gabosine C

N Biduś, P Banachowicz, S Buda - Tetrahedron, 2020 - Elsevier
Abstract Synthesis of (+)-Pericosine B,(+)-Pericosine C,(+)-COTC and a 7-chloro-analogue
of (+)-Gabosine C was achieved via tandem seleno-Michael/aldol reactions as key steps …

Synthesis and biological evaluation of the novel growth inhibitor streptol glucoside, isolated from an obligate plant symbiont

CC Hsiao, S Sieber, A Georgiou, A Bailly… - … A European Journal, 2019 - Wiley Online Library
The plant Psychotria kirkii hosts an obligatory bacterial symbiont, Candidatus Burkholderia
kirkii, in nodules on their leaves. Recently, a glucosylated derivative of (+)‐streptol,(+) …

A divergent strategy to synthesize gabosines featuring a switchable two-way aldol cyclization

X Yang, P Yuan, F Shui, Y Zhou, X Chen - Organic & Biomolecular …, 2019 - pubs.rsc.org
Gabosines and their natural analogues, belonging to C7 carbasugars, have attracted great
attention in synthesis due to their rich structural variety and promising biological activities. A …

Practical synthesis of phthalascidin and zalypsis antitumor agents

Q Zhou, J Jia, Y Wang, R Chen, X Chen - Tetrahedron Letters, 2021 - Elsevier
The first total synthesis of zalypsis and the practical synthesis of phthalascidin (Pt-650) are
achieved through the Pictet-Spengler cyclization coupling strategy. The direct iodination of …

A flexible and divergent strategy to flavonoids with a chiral a-ring featuring intramolecular Michael addition: stereoselective synthesis of (+)-cryptocaryone,(+) …

X Liu, J Jia, Y Jia, H Gu, J Luo, X Chen - Organic letters, 2018 - ACS Publications
A flexible strategy has been developed to synthesize divergent flavonoids bearing a chiral A-
ring. As two key steps, the coupling via a boron-mediated aldol condensation and the …

A divergent approach to synthesize C7 epoxyquinones from (–)-shikimic acid

F Wu, L Huang, M Wang, Y Wang, X Chen - Tetrahedron Letters, 2024 - Elsevier
A collective synthesis of the C7 epoxyquinones has been achieved by a concise and flexible
strategy, in which the employment of (–)-shikimic acid as starting material permits the rapid …

Enantioselective Total Synthesis of (+)-Penostatins A and C

Y Jia, M Wang, F Wu, X Chen - Organic Letters, 2023 - ACS Publications
A stereoselective and column-economic approach to (+)-penostatins A and C has been
developed. The multisubstituted A ring and B/C rings in their unique tricyclic framework are …