Enzymes control chemical reactions that are key to life processes, and allow them to take
place on the time scale needed for synchronization between the relevant reaction cycles. In …

Enzymes are dynamic entities, and their dynamic properties are clearly linked to their
biological function. It follows that dynamics ought to play an essential role in enzyme …

High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and
lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly …

Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases
(PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and …

The advent of laboratory directed evolution yielded a fruitful crosstalk between the
disciplines of molecular evolution and bio-engineering. Here, we outline recent …

Conformational flexibility plays a critical role in enzyme function and regulation.
Conformational changes, which can occur on multiple length and time scales, facilitate, for …

Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a
broad range of substrates, including organophosphates, esters, and carbonates …

Organophosphorus compounds (OPCs) are able to interact with various biological targets in
living organisms, including enzymes. The binding of OPCs to enzymes does not always lead …

Several enzymes from the metallo-β-lactamase-like family of lactonases (MLLs) degrade N-
acyl L-homoserine lactones (AHLs). They play a role in a microbial communication system …

Reactions involving the transfer of a phosphoryl (− PO32–) group are fundamental to cellular
metabolism. These reactions are catalyzed by enzymes, often large and complex, belonging …