[HTML][HTML] Current trends in pharmaceutical treatment of dry eye disease: A review

HB Mohamed, BN Abd El-Hamid, D Fathalla… - European Journal of …, 2022 - Elsevier
Dry eye disease (DED), keratoconjunctivitis sicca or dysfunctional tear syndrome, is the most
prevalent ophthalmic disease which affects a substantial segment of people worldwide with …

Novel drug delivery systems for the management of dry eye

N Nagai, H Otake - Advanced drug delivery reviews, 2022 - Elsevier
Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted
considerable research interest. Conventional therapy for DED involves the use of artificial …

Anti‐oxidative and anti‐inflammatory micelles: break the dry eye vicious cycle

S Li, Z Lu, Y Huang, Y Wang, Q Jin, X Shentu… - Advanced …, 2022 - Wiley Online Library
Dry eye disease (DED) impacts≈ 30% of the world's population and causes serious ocular
discomfort and even visual impairment. Inflammation is one core cause of the DED vicious …

Formulation considerations for the management of dry eye disease

P Agarwal, JP Craig, ID Rupenthal - Pharmaceutics, 2021 - mdpi.com
Dry eye disease (DED) is one of the most common ocular surface disorders characterised by
a deficiency in quality and/or quantity of the tear fluid. Due to its multifactorial nature …

Dry eye syndrome: comprehensive etiologies and recent clinical trials

R Huang, C Su, L Fang, J Lu, J Chen… - International …, 2022 - Springer
Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than
ever given the rapid pace of modernization, which is directly associated with many of the …

Efficacy and safety of a water-free topical cyclosporine, 0.1%, solution for the treatment of moderate to severe dry eye disease: the ESSENCE-2 randomized clinical …

EK Akpek, DL Wirta, JE Downing, J Tauber… - JAMA …, 2023 - jamanetwork.com
Importance Dry eye disease (DED) is a common public health problem with significant
impact on vision-related quality of life and well-being of patients. Medications with rapid …

[HTML][HTML] A lacrimal duct drug delivery system based on photo-induced hydrogel for dry eye and allergic conjunctivitis therapy

T Lin, W Wang, T Chen, B Bao, T Liu, H Zhao… - Composites Part B …, 2023 - Elsevier
To design an ocular drug delivery system is challenging due to the limited space of the
ocular surface and high sensitivity of the cornea. Here, we developed a lacrimal duct drug …

Membrane Fusion‐Mediated Loading of Therapeutic siRNA into Exosome for Tissue‐Specific Application

M Xie, Y Wu, Y Zhang, R Lu, Z Zhai, Y Huang… - Advanced …, 2024 - Wiley Online Library
Tissue‐specific delivery of oligonucleotide therapeutics beyond the liver remains a key
challenge in nucleic acid drug development. To address this issue, exploiting exosomes as …

A review of imaging biomarkers of the ocular surface

WW Binotti, B Bayraktutar, MC Ozmen, SM Cox… - Eye & contact …, 2020 - journals.lww.com
A biomarker is a “characteristic that is measured as an indicator of normal biological
processes, pathogenic processes, or responses to an exposure or intervention, including …

Management of inflammation in dry eye disease: Recommendations from a European panel of experts

EM Messmer, S Ahmad… - European Journal …, 2023 - journals.sagepub.com
Introduction Early initiation of anti-inflammatory therapies is recommended for dry eye
disease (DED) to break the vicious cycle of pathophysiology. However, there is limited …