Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms

A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …

Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Fipronil insecticide toxicology: oxidative stress and metabolism

X Wang, MA Martínez, Q Wu, I Ares… - Critical reviews in …, 2016 - Taylor & Francis
Fipronil (FIP) is widely used across the world as a broad-spectrum phenylpyrazole
insecticide and veterinary drug. FIP was the insecticide to act by targeting the γ-aminobutyric …

Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury

YO Mukhamedshina, OA Gracheva… - Neural regeneration …, 2019 - journals.lww.com
Cell-based technologies are used as a therapeutic strategy in spinal cord injury (SCI).
Mesenchymal stem cells (MSCs), which secrete various neurotrophic factors and cytokines …

The influence of exercise on oxidative stress after spinal cord injury: a narrative review

G Maugeri, A Amato, M Sortino, VD′ Agata… - Antioxidants, 2023 - mdpi.com
Spinal cord injury (SCI) is an irreversible disease resulting in partial or total loss of sensory
and motor function. The pathophysiology of SCI is characterized by an initial primary injury …

Oxidative DNA damage in the pathophysiology of spinal cord injury: seems obvious, but where is the evidence?

EEM Scheijen, S Hendrix, DM Wilson III - Antioxidants, 2022 - mdpi.com
Oxidative stress occurs at various phases of spinal cord injury (SCI), promoting detrimental
processes such as free radical injury of proteins, nucleic acids, lipids, cytoskeleton, and …

Meloxicam prevents COX‐2‐mediated post‐surgical inflammation but not pain following laparotomy in mice

JV Roughan, HGMJ Bertrand… - European Journal of …, 2016 - Wiley Online Library
Background Inflammation is thought to be a major contributor to post‐surgical pain, so non‐
steroidal anti‐inflammatory drugs (NSAID s) are commonly used analgesics. However …

Effects of free radical initiators on polyethylene glycol dimethacrylate hydrogel properties and biocompatibility

TS Wilems, X Lu, YE Kurosu, Z Khan… - … Research Part A, 2017 - Wiley Online Library
Many studies have utilized Irgacure 2959 photopolymerized poly (ethylene glycol)(PEG)
hydrogels for tissue engineering application development. Due to the limited penetration of …

Neuronal death in the contralateral un-injured retina after unilateral axotomy: Role of microglial cells

F Lucas-Ruiz, C Galindo-Romero… - International Journal of …, 2019 - mdpi.com
For years it has been known that unilateral optic nerve lesions induce a bilateral response
that causes an inflammatory and microglial response in the contralateral un-injured retinas …

The neurobehavioral effects of buprenorphine and meloxicam on a blast-induced traumatic brain injury model in the rat

LM Anderson, S Samineni, DM Wilder, M Lara… - Frontiers in …, 2021 - frontiersin.org
Previous findings have indicated that pain relieving medications such as opioids and non-
steroidal anti-inflammatory drugs (NSAIDs) may be neuroprotective after traumatic brain …