Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity

M Cooke, MG Kazanietz - Science Signaling, 2022 - science.org
Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Ras activation revisited: role of GEF and GAP systems

A Hennig, R Markwart, MA Esparza-Franco… - Biological …, 2015 - degruyter.com
Ras is a prototypical small G-protein and a central regulator of growth, proliferation and
differentiation processes in virtually every nucleated cell. As such, Ras becomes engaged …

Regulation and function of the RasGRP family of Ras activators in blood cells

JC Stone - Genes & cancer, 2011 - journals.sagepub.com
Ras guanyl nucleotide releasing proteins (RasGRPs) are guanyl nucleotide exchange
factors that activate Ras and related GTPases such as Rap. Like Sos proteins, RasGRPs …

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells

JE Jun, I Rubio, JP Roose - Frontiers in immunology, 2013 - frontiersin.org
The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated
downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors …

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

JS Iwig, Y Vercoulen, R Das, T Barros, A Limnander… - Elife, 2013 - elifesciences.org
RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in
lymphocyte development. RasGRP1 is important in some cancers and autoimmune …

A focused review of ras guanine nucleotide-releasing protein 1 in immune cells and cancer

TC Hsu, GOL Rodrigues, H Winer, JA Hixon… - International journal of …, 2023 - mdpi.com
Four Ras guanine nucleotide-releasing proteins (RasGRP1 through 4) belong to the family
of guanine nucleotide exchange factors (GEFs). RasGRPs catalyze the release of GDP from …

RasGRP Ras guanine nucleotide exchange factors in cancer

O Ksionda, A Limnander, JP Roose - Frontiers in biology, 2013 - Springer
RasGRP proteins are activators of Ras and other related small GTPases by the virtue of
functioning as guanine nucleotide exchange factors (GEFs). In vertebrates, four RasGRP …

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

SR Daley, KM Coakley, DY Hu, KL Randall, CN Jenne… - elife, 2013 - elifesciences.org
Missense variants are a major source of human genetic variation. Here we analyze a new
mouse missense variant, Rasgrp1 Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras …

Phosphorylation of RasGRP1 by Shc3 prevents RasGRP1 degradation and contributes to Ras/c-Jun activation in hepatocellular carcinoma

X Zhang, Y Liu, R Yang, Y Guo, M Yan, Y Xiao… - Molecular and Cellular …, 2024 - Springer
Ras guanine nucleotide-releasing protein 1 (RasGRP1), a Ras activator, is upregulated in
hepatocellular carcinoma (HCC) and other kinds of cancer and is associated with the poor …

Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation

M Oh, SY Kim, JE Gil, JS Byun, DW Cha, B Ku… - Scientific Reports, 2020 - nature.com
Nurr1, a transcription factor belonging to the orphan nuclear receptor, has an essential role
in the generation and maintenance of dopaminergic neurons and is important in the …