Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …
and correlate with morbidity and mortality. Consequently, identification of genetic and …
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
MA Ferreira, JM Vonk, H Baurecht, I Marenholz… - Nature …, 2017 - nature.com
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals, partly because of a shared genetic origin,,. To identify shared risk variants …
same individuals, partly because of a shared genetic origin,,. To identify shared risk variants …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
DNA methylation and regulation of gene expression: Guardian of our health
GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …
70-year legacy of the Framingham Heart Study
Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …