Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

PIEZO1 is a cation channel that is activated by mechanical forces such as fluid shear stress
or membrane stretch. PIEZO1 loss-of-function mutations in patients are associated with …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Over 300 billion of cells die every day in the human body, producing a large number of
endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell …

Lymphangitis and the formation of tertiary lymphoid organs (TLOs) in the mesentery are
features of Crohn's disease. Here, we examined the genesis of these TLOs and their impact …

Patients with congenital lymphedema suffer from tissue swelling in part due to mutations in
genes regulating lymphatic valve development. Lymphatic valve leaflets grow and are …

The lymphatic system plays crucial roles in tissue homeostasis, lipid absorption, and
immune cell trafficking. Although lymphatic valves ensure unidirectional lymph flows, the …