Untangling the roles of TOP2A and TOP2B in transcription and cancer
L Uusküla-Reimand, MD Wilson - Science advances, 2022 - science.org
Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
SJ Kierans, CT Taylor - The Journal of physiology, 2021 - Wiley Online Library
Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …
[HTML][HTML] Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
Network medicine framework for identifying drug-repurposing opportunities for COVID-19
D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
A reference map of the human binary protein interactome
Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …
understanding of the interactome networks that mediate genotype–phenotype relationships …
Cryo-EM structures of human m6A writer complexes
Abstract N 6-methyladenosine (m6A) is the most abundant ribonucleotide modification
among eukaryotic messenger RNAs. The m6A “writer” consists of the catalytic subunit m6A …
among eukaryotic messenger RNAs. The m6A “writer” consists of the catalytic subunit m6A …
Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal
Summary N 6-methyladenosine (m 6 A) is an abundant modification in eukaryotic mRNA,
regulating mRNA dynamics by influencing mRNA stability, splicing, export, and translation …
regulating mRNA dynamics by influencing mRNA stability, splicing, export, and translation …
CORUM: the comprehensive resource of mammalian protein complexes—2019
M Giurgiu, J Reinhard, B Brauner… - Nucleic acids …, 2019 - academic.oup.com
CORUM is a database that provides a manually curated repository of experimentally
characterized protein complexes from mammalian organisms, mainly human (67%), mouse …
characterized protein complexes from mammalian organisms, mainly human (67%), mouse …
Architecture of the human interactome defines protein communities and disease networks
The physiology of a cell can be viewed as the product of thousands of proteins acting in
concert to shape the cellular response. Coordination is achieved in part through networks of …
concert to shape the cellular response. Coordination is achieved in part through networks of …
To degrade or not to degrade: mechanisms and significance of endocytic recycling
PJ Cullen, F Steinberg - Nature reviews Molecular cell biology, 2018 - nature.com
Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …