Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Abstract Spilanthol (C14H23NO, 221.339 g/mol) is a bioactive compound that is found in
many different plants that are used as traditional remedies throughout the world. It is present …

Spilanthes acmella, a well known antitoothache plant with high medicinal usages, has been
recognized as an important medicinal plant and has an increasingly high demand …

Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …

Anacyclus pyrethrum (L.) is a plant widely used in Moroccan traditional medicine to treat
inflammatory and painful diseases. The objective of the present study was to evaluate the …

Interest in alkylamide, as a class of compound, has grown tremendously in recent years.
This interest is due to the many presumed benefits in food, cosmetics, and medicine. This …

Human pathologies, environmental pollution, and resistance phenomena caused by the
intensive use of chemical pesticides have shifted the attention of the agrochemical industries …

Alkamides are natural products formed by connecting straight-chain, mostly unsaturated,
aliphatic acids with various amines by an amide linkage. More than 300 derivatives are …

Herbal medicines are an integral element of alternative medical care in Mexico, and the best
testimony to their efficacy and cultural value is their persistence in contemporary Mexican …

Activated macrophages upregulate inducible nitric oxide synthase (iNOS) leading to the
profuse production of nitric oxide (NO) and, eventually, tissue damage. Using macrophage …