Muscle metabolism and atrophy: let's talk about sex

ME Rosa-Caldwell, NP Greene - Biology of sex differences, 2019 - Springer
Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies
affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular …

The androgen receptor in prostate cancer: Effect of structure, ligands and spliced variants on therapy

EA Messner, TM Steele, MM Tsamouri, N Hejazi… - Biomedicines, 2020 - mdpi.com
The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …

INVITED REVIEW: Inhibitors of myostatin as methods of enhancing muscle growth and development

PR Chen, K Lee - Journal of animal science, 2016 - academic.oup.com
With the increasing demand for affordable, high-quality meat, livestock and poultry
producers must continually find ways to maximize muscle growth in their animals without …

Crossbred young bulls and heifers sired by double-muscled Piemontese or Belgian Blue bulls exhibit different effects of sexual dimorphism on fattening performance …

G Bittante, A Cecchinato, F Tagliapietra, R Verdiglione… - Meat science, 2018 - Elsevier
Abstract As double-muscled Belgian Blue (BB) and Piemontese (PIEM) breeds are heavily
selected for different objectives (the former mainly for muscularity, the latter for ease of …

Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis

Z Deng, P Luo, W Lai, T Song, J Peng… - … and biophysical research …, 2017 - Elsevier
Growth of skeletal muscle is dependent on the protein synthesis, and the rate of protein
synthesis is mainly regulated in the stage of translation initiation and elongation. Myostatin …

[PDF][PDF] Frameshift mutation in myostatin gene by zinc-finger nucleases results in a significant increase in muscle mass in Meishan sows.

H Bi, S Xie, C Cai, L Qian, S Jiang… - Czech Journal of …, 2020 - cjas.agriculturejournals.cz
Myostatin (MSTN) is a negative regulator of skeletal muscle growth and development. A
significant increase in skeletal muscle was observed in Mstn−/− mice compared with wild …

Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

LL Qian, P GAO, S JIANG, Q WANG, C CAI… - Journal of Integrative …, 2016 - Elsevier
Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, is a
dominant inhibitor that acts to limit skeletal muscle growth and development. In this study …

Exploring CRISPR/Cas9 as a tool to investigate the role of Androgen Receptor in basal to luminal cell differentiation using human prostate cell lines

G McDonald - 2018 - etheses.whiterose.ac.uk
The prostate epithelium is defined in terms of a hierarchical structure, where each cell type
can differentiate into the next cell in the lineage until terminally differentiated luminal cells …

Muscle Fiber Hyperplasia in Leg Muscle of Transgenic Quail Overexpressing an Alternative Splicing Variant of Myostatin

PR Chen - 2016 - rave.ohiolink.edu
Increasing muscle mass is one of the primary goals of the United States poultry industry;
however, skeletal muscle development at the molecular level is not fully understood …