Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management

A Nabavi-Rad, A Sadeghi, H Asadzadeh Aghdaei… - Gut …, 2022 - Taylor & Francis
As Helicobacter pylori management has become more challenging and less efficient over
the last decade, the interest in innovative interventions is growing by the day. Probiotic co …

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

J Baj, I Korona-Głowniak, A Forma, A Maani, E Sitarz… - Cells, 2020 - mdpi.com
Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of
the world's population. Approximately 20% of the infected patients develop gastric ulcers or …

Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

S Ansari, Y Yamaoka - International journal of molecular sciences, 2020 - mdpi.com
Helicobacter pylori causes persistent infection in the gastric epithelium of more than half of
the world's population, leading to the development of severe complications such as peptic …

The Helicobacter pylori cag type IV secretion system

TL Cover, DB Lacy, MD Ohi - Trends in microbiology, 2020 - cell.com
Colonization of the human stomach with Helicobacter pylori strains containing the cag
pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity …

Changes of the gastric mucosal microbiome associated with histological stages of gastric carcinogenesis

Z Wang, X Gao, R Zeng, Q Wu, H Sun, W Wu… - Frontiers in …, 2020 - frontiersin.org
The changes of gastric microbiome across stages of neoplastic progression remain poorly
understood, especially for intraepithelial neoplasia (IN) which has been recognized as a …

The interactions between oral-gut axis microbiota and Helicobacter pylori

X Chen, N Wang, J Wang, B Liao, L Cheng… - Frontiers in Cellular and …, 2022 - frontiersin.org
In the human body, each microbial habitat exhibits a different microbial population pattern,
and these distinctive microflorae are highly related to the development of diseases. The …

Pathogenesis of Helicobacter pylori infection

M Denic, E Touati, H De Reuse - Helicobacter, 2020 - Wiley Online Library
The original strategies developed by Helicobacter pylori to persistently colonise its host and
to deregulate its cellular functions make this bacterium an outstanding model to study host …

Propionibacterium acnes overabundance in gastric cancer promote M2 polarization of macrophages via a TLR4/PI3K/Akt signaling

Q Li, W Wu, D Gong, R Shang, J Wang, H Yu - Gastric Cancer, 2021 - Springer
Abstract Objective Eradication of Helicobacter pylori (H. pylori) could not completely prevent
the progression of gastric cancer (GC), suggesting that non-H. pylori bacteria may …

Therapeutic approach targeting gut microbiome in gastrointestinal infectious diseases

Z Han, Y Min, K Pang, D Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
While emerging evidence highlights the significance of gut microbiome in gastrointestinal
infectious diseases, treatments like Fecal Microbiota Transplantation (FMT) and probiotics …