The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

Analyzing contractile force, the most important and best understood function of
cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening
cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of …

Normal cardiac function requires an appropriate and regular beating rate (cardiac rhythm).
When the heart rhythm is too fast or too slow, cardiac function can be impaired, with …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

The human ether-à-go-go related gene (hERG) K+ channel is of great interest for both basic
researchers and clinicians because its blockade by drugs can lead to QT prolongation …

Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …