Although originally multi-ethnic in its structure, nowadays the Calabria region of southern
Italy represents an area with low genetic heterogeneity and a high level of consanguinity …

Background Aggregates of TAR DNA-binding protein of 43 kDa (TDP-43) represent the
pathological hallmark of most amyotrophic lateral sclerosis (ALS) and of nearly 50% of …

Background and objectives Genetic variants in the gene TARDBP, encoding TDP‐43
protein, are associated with amyotrophic lateral sclerosis (ALS) in familial (fALS) and …

Abstract TAR DNA binding protein (TDP-43) is a DNA/RNA binding protein whose
pathological role in amyotrophic lateral sclerosis (ALS) and frontal temporal lobe dementia …

Using exome sequencing, we analyzed 196 participants of the Cretan Aging Cohort (CAC;
95 with Alzheimer's disease [AD], 20 with mild cognitive impairment [MCI], and 81 cognitively …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that
predominately involves the motor neurons in the brain and spinal cord. The TARDBP gene …

Although originally multi-ethnic in its structure, nowadays the Calabria region of southern
Italy represents an area with low genetic heterogeneity and a high level of consanguinity …

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder that affects motor
neurons. ALS genetic landscape continues to shift as the number of genes associated with …