Recent progress in pancreatic cancer

CL Wolfgang, JM Herman, DA Laheru… - CA: a cancer journal …, 2013 - Wiley Online Library
Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas.

FR Spitz, JL Abbruzzese, JE Lee, PW Pisters… - Journal of Clinical …, 1997 - ascopubs.org
PURPOSE The effects of preoperative versus postoperative fluorouracil (5-FU)-based
chemotherapy and irradiation on treatment toxicity, duration of treatment, tumor recurrence …

Impact of resection margin status on recurrence and survival in pancreatic cancer surgery

WS Tummers, JV Groen… - Journal of British …, 2019 - academic.oup.com
Background The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is
poor and selection of patients for surgery is challenging. This study examined the impact of a …

A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer

JP Neoptolemos, DD Stocken, H Friess… - … England Journal of …, 2004 - Mass Medical Soc
Background The effect of adjuvant treatment on survival in pancreatic cancer is unclear. We
report the final results of the European Study Group for Pancreatic Cancer 1 Trial and …

Resected adenocarcinoma of the pancreas—616 patients: results, outcomes, and prognostic indicators

TA Sohn, CJ Yeo, JL Cameron, L Koniaris… - Journal of …, 2000 - Elsevier
This large-volume, single-institution review examines factors influencing long-term survival
after resection in patients with adenocarcinoma of the head, neck, uncinate process, body …

Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a “true” R0 resection?

IT Konstantinidis, AL Warshaw, JN Allen… - Annals of …, 2013 - journals.lww.com
Objective: Patients who undergo an R0 resection of their pancreatic ductal adenocarcinoma
(PDAC) have an improved survival compared with patients who undergo an R1 resection. It …

Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial

JP Neoptolemos, JA Dunn, DD Stocken, J Almond… - The Lancet, 2001 - thelancet.com
Background The role of adjuvant treatment in pancreatic cancer remains uncertain. The
European Study Group for Pancreatic Cancer (ESPAC) assessed the roles of …

Most pancreatic cancer resections are R1 resections

I Esposito, J Kleeff, F Bergmann, C Reiser… - Annals of surgical …, 2008 - Springer
Background Curative resection has been shown to be one of the key factors influencing
survival of pancreatic ductal adenocarcinoma (PDAC) patients. Although general guidelines …

Pancreaticoduodenectomy for cancer of the head of the pancreas 201 patients

CJ Yeo, JL Cameron, KD Lillemoe, JV Sitzmann… - Annals of …, 1995 - journals.lww.com
Objective: This single-institution study examined the outcome after
pancreaticoduodenectomy in patients with adenocarcinoma of the head of the pancreas …

Redefining the R1 resection in pancreatic cancer

CS Verbeke, D Leitch, KV Menon… - Journal of British …, 2006 - academic.oup.com
Background Resection margin (RM) status in pancreatic head adenocarcinoma is assessed
histologically, but pathological examination is not standardized. The aim of this study was to …