Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

J Isaković, K Šerer, B Barišić, D Mitrečić - Frontiers in bioengineering …, 2023 - frontiersin.org
Neurological disorders are recognized as major causes of death and disability worldwide.
Because of this, they represent one of the largest public health challenges. With awareness …

The challenging treatment of cisplatin-resistant tumors: State of the art and future perspectives

G Coffetti, M Moraschi, G Facchetti, I Rimoldi - Molecules, 2023 - mdpi.com
One of the main problems in chemotherapy using platinum drugs as anticancer agents is the
resistance phenomenon. Synthesizing and evaluating valid alternative compounds is …

Precision nanomedicine with bio-inspired nanosystems: recent trends and challenges in mesenchymal stem cells membrane-coated bioengineered nanocarriers in …

MS Baig, A Ahmad, RR Pathan, RK Mishra - Journal of Xenobiotics, 2024 - mdpi.com
In the recent past, the formulation and development of nanocarriers has been elaborated
into the broader fields and opened various avenues in their preclinical and clinical …

Mesenchymal Stem Cell (MSC)-Based Drug Delivery into the Brain across the Blood–Brain Barrier

T Tashima - Pharmaceutics, 2024 - mdpi.com
At present, stem cell-based therapies using induced pluripotent stem cells (iPSCs) or
mesenchymal stem cells (MSCs) are being used to explore the potential for regenerative …

Mesenchymal stem cells-derived secretome and extracellular vesicles: perspective and challenges in cancer therapy and clinical applications

J Gemayel, D Chaker, G El Hachem, M Mhanna… - Clinical and …, 2023 - Springer
Stem cell-based therapies have been foreshowed as a promising therapeutic approach for
the treatment of several diseases. However, in the cancer context, results obtained from …

Nanocarrier-based drug delivery via cell-hitchhiking: emphasizing pharmacokinetic perspective towards taming the “big-old” tumors

P Famta, S Shah, N Jain, DA Srinivasarao… - Journal of Drug Delivery …, 2023 - Elsevier
Nanocarriers (NCs) are widely explored in the development of anti-tumor therapeutics. NCs
offer many advantages over conventional drug delivery systems (DDS) such as improved …

3D hUC-MSC spheroids exhibit superior resistance to autophagy and apoptosis of granulosa cells in POF rat model

W Dai, H Yang, B Xu, T He, L Liu, Z Zhang… - …, 2024 - rep.bioscientifica.com
In brief This study reveals that orthotopic transplantation of 3D hUC-MSC spheroids is more
effective than monolayer-cultured hUC-MSCs in improving POF and distinctly reducing …

[HTML][HTML] Fucoidan/chitosan hydrogels as carrier for sustained delivery of platelet-rich fibrin containing bioactive molecules

K Egle, E Dohle, V Hoffmann, I Salma… - International Journal of …, 2024 - Elsevier
Abstract Platelet-rich fibrin (PRF), derived from human blood, rich in wound healing
components, has drawbacks in direct injections, such as rapid matrix degradation and …

Signal pathways and microRNAs in osteosarcoma growth and the dual role of mesenchymal stem cells in oncogenesis

N Todosenko, I Khlusov, K Yurova… - International Journal of …, 2023 - mdpi.com
The major challenges in Osteosarcoma (OS) therapy are its heterogeneity and drug
resistance. The development of new therapeutic approaches to overcome the major growth …

The role of mesenchymal stem cells in cancer and prospects for their use in cancer therapeutics

J Tang, Y Chen, C Wang, Y Xia, T Yu, M Tang… - MedComm, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) are recruited by malignant tumor cells to the tumor
microenvironment (TME) and play a crucial role in the initiation and progression of …